Star-crossed : not favored by the stars : ill-fated.
Examples of star-crossed lovers in film: Tommy/Kathy - Never Let Me Go, Romeo/Juliet - Romeo + Juliet, Jack/Rose - Titanic, Cecelia/Robbie - Atonement, Katniss/Peeta - The Hunger Games, Phillip/Syrena - Pirates of the Caribbean, Arwen/Aragorn - Lord of the Rings, and Fanny/John Keats - Bright Star.